Each month the IOCN team will illustrate have a clinical case study to provide an opportunity for healthcare professionals to learn, discuss and improve their understanding of immuno-oncology treatments and their side effects. 

• A 41 year old gentleman who was diagnosed with metastatic melanoma in January 2018
• He was treated with anti-PD1/anti-CTLA4 combination immunotherapy
• After 2 cycles of treatment he experienced  eye pain and inflammation and came into the cancer centre for review

MRI: Progression of the symmetrical proptosis bilaterally. Bulkiness to the extraocular muscles

• March-July 2018: He was treated with high dose steroids and MTX with good resolution of symptoms after 15 weeks of treatment

  July 2018: Complete response to IO treatment

• August 2018: Restarted monotherapy IO. Flare of arthralgia, back pain and headache periodically but managed with short term immunosuppression and treatment breaks
• January 2020: Completed 2 years of therapy
• August 2023: Ongoing complete response. Long term mild side effects managed under an IO late effects clinic

*patient has given permission for his picture to be used and contributed them to an article in the Huffington Post:

https://www.huffingtonpost.co.uk/entry/exclusive-i-thought-i-wouldnt-see-another-christmas-but-miraculous-treatment-has-cleared-my-tumours_uk_5c05729fe4b066b5cfa492a8?guccounter=1&guce_referrer_us=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_cs=PKQdEhpXNhtpeMAX-1XmtA 

To find more IO case studies and previous IO case of the month visit our case library